Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H(+) leak

CONTEXT: The toxicity of atractyloside/carboxyatractyloside is generally well recognized and commonly ascribed to the inhibition of mitochondrial ADP/ATP carriers, which are pivotal for oxidative phosphorylation. However, these glycosides may 'paralyze' additional target proteins. OBJECTIV...

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Detalles Bibliográficos
Autor principal: Woyda-Ploszczyca, Andrzej M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946330/
https://www.ncbi.nlm.nih.gov/pubmed/36799406
http://dx.doi.org/10.1080/13880209.2023.2168704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946330/
https://www.ncbi.nlm.nih.gov/pubmed/36799406
http://dx.doi.org/10.1080/13880209.2023.2168704

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