PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells

Myelodysplastic syndrome (MDS) is a clonal malignancy arising in hematopoietic stem cells (HSCs). The mechanisms of MDS initiation in HSCs are still poorly understood. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is frequently activated in acute myeloid leukemia, but in MDS, PI3K/AKT is ofte...

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Detalles Bibliográficos
Autores principales: Ames, Kristina, Kaur, Imit, Shi, Yang, Tong, Meng M., Sinclair, Taneisha, Hemmati, Shayda, Glushakow-Smith, Shira G., Tein, Ellen, Gurska, Lindsay, Steidl, Ulrich, Dubin, Robert, Shan, Jidong, Montagna, Cristina, Pradhan, Kith, Verma, Amit, Gritsman, Kira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946350/
https://www.ncbi.nlm.nih.gov/pubmed/36812307
http://dx.doi.org/10.1126/sciadv.ade8222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946350/
https://www.ncbi.nlm.nih.gov/pubmed/36812307
http://dx.doi.org/10.1126/sciadv.ade8222

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