Reduced insulin signaling in neurons induces sex-specific health benefits

Reduced activity of insulin/insulin-like growth factor signaling (IIS) extends health and life span in mammals. Loss of the insulin receptor substrate 1 (Irs1) gene increases survival in mice and causes tissue-specific changes in gene expression. However, the tissues underlying IIS-mediated longevit...

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Detalles Bibliográficos
Autores principales: Baghdadi, Maarouf, Nespital, Tobias, Mesaros, Andrea, Buschbaum, Sandra, Withers, Dominic J., Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946356/
https://www.ncbi.nlm.nih.gov/pubmed/36812323
http://dx.doi.org/10.1126/sciadv.ade8137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946356/
https://www.ncbi.nlm.nih.gov/pubmed/36812323
http://dx.doi.org/10.1126/sciadv.ade8137

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