De novo design of luciferases using deep learning

De novo enzyme design has sought to introduce active sites and substrate-binding pockets that are predicted to catalyse a reaction of interest into geometrically compatible native scaffolds(1,2), but has been limited by a lack of suitable protein structures and the complexity of native protein seque...

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Detalles Bibliográficos
Autores principales: Yeh, Andy Hsien-Wei, Norn, Christoffer, Kipnis, Yakov, Tischer, Doug, Pellock, Samuel J., Evans, Declan, Ma, Pengchen, Lee, Gyu Rie, Zhang, Jason Z., Anishchenko, Ivan, Coventry, Brian, Cao, Longxing, Dauparas, Justas, Halabiya, Samer, DeWitt, Michelle, Carter, Lauren, Houk, K. N., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946828/
https://www.ncbi.nlm.nih.gov/pubmed/36813896
http://dx.doi.org/10.1038/s41586-023-05696-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946828/
https://www.ncbi.nlm.nih.gov/pubmed/36813896
http://dx.doi.org/10.1038/s41586-023-05696-3

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