Dissecting cell identity via network inference and in silico gene perturbation

Cell identity is governed by the complex regulation of gene expression, represented as gene-regulatory networks(1). Here we use gene-regulatory networks inferred from single-cell multi-omics data to perform in silico transcription factor perturbations, simulating the consequent changes in cell ident...

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Detalles Bibliográficos
Autores principales: Kamimoto, Kenji, Stringa, Blerta, Hoffmann, Christy M., Jindal, Kunal, Solnica-Krezel, Lilianna, Morris, Samantha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946838/
https://www.ncbi.nlm.nih.gov/pubmed/36755098
http://dx.doi.org/10.1038/s41586-022-05688-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9946838/
https://www.ncbi.nlm.nih.gov/pubmed/36755098
http://dx.doi.org/10.1038/s41586-022-05688-9

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