In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization

Despite high anticancer activity, doxorubicin (DOX)-induced cardiotoxicity (DIC) limits the extensive utility of DOX in a clinical setting. Amongst various strategies explored, dexrazoxane (DEX) remains the only cardioprotective agent to be approved for DIC. In addition, altering the dosing regimen...

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Detalles Bibliográficos
Autores principales: Mody, Hardik, Vaidya, Tanaya R., Ait-Oudhia, Sihem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947016/
https://www.ncbi.nlm.nih.gov/pubmed/36813809
http://dx.doi.org/10.1038/s41598-023-29964-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947016/
https://www.ncbi.nlm.nih.gov/pubmed/36813809
http://dx.doi.org/10.1038/s41598-023-29964-4

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