Increased constraints on MC4R during primate and human evolution

The melanocortin 4 receptor (MC4R) is routinely investigated for the role it plays in human obesity, as mutations in MC4R are the most common dominantly inherited form of the disease. As little is known about the evolutionary history of this locus, we investigated patterns of variation at MC4R in a...

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Detalles Bibliográficos
Autores principales: Hughes, David A., Hinney, Anke, Brumm, Harald, Wermter, Anne-Kathrin, Biebermann, Heike, Hebebrand, Johannes, Stoneking, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2008
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947067/
https://www.ncbi.nlm.nih.gov/pubmed/19011902
http://dx.doi.org/10.1007/s00439-008-0591-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947067/
https://www.ncbi.nlm.nih.gov/pubmed/19011902
http://dx.doi.org/10.1007/s00439-008-0591-8

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