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CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis

Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. Here we described a genome-wide screen by CRISPR activation (CRISPRa) library in vivo for drivers of HCC growth and metastasis. Pathological results showed the cell population formed highly metastatic tumors...

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Detalles Bibliográficos
Autores principales:	Zhang, Bei, Ren, Zhiyao, Zheng, Hongmei, Lin, Meilan, Chen, Guobing, Luo, Oscar Junhong, Zhu, Guodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947337/ https://www.ncbi.nlm.nih.gov/pubmed/36843840 http://dx.doi.org/10.1016/j.isci.2023.106099

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