In-Cell Chemical Crosslinking Identifies Hotspots for SQSTM-1/p62-IκBα Interaction That Underscore a Critical Role of p62 in Limiting NF-κB Activation Through IκBα Stabilization

We have previously documented that in liver cells, the multifunctional protein scaffold p62/SQSTM1 is closely associated with IκBα, an inhibitor of the transcriptional activator NF-κB. Such an intimate p62-IκBα association we now document leads to a marked 18-fold proteolytic IκBα-stabilization, ena...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Trnka, Michael J., He, Liang, Burlingame, A.L., Correia, Maria Almira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947424/
https://www.ncbi.nlm.nih.gov/pubmed/36634736
http://dx.doi.org/10.1016/j.mcpro.2023.100495

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947424/
https://www.ncbi.nlm.nih.gov/pubmed/36634736
http://dx.doi.org/10.1016/j.mcpro.2023.100495

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