Modeling C3 glomerulopathies: C3 convertase regulation on an extracellular matrix surface

INTRODUCTION: C3 glomerulopathies (C3G) are ultra-rare complement-mediated diseases that lead to end-stage renal disease (ESRD) within 10 years of diagnosis in ~50% of patients. Overactivation of the alternative pathway (AP) of complement in the fluid phase and on the surface of the glomerular endot...

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Detalles Bibliográficos
Autores principales: Pisarenka, Sofiya, Meyer, Nicole C., Xiao, Xue, Goodfellow, Renee, Nester, Carla M., Zhang, Yuzhou, Smith, Richard J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947773/
https://www.ncbi.nlm.nih.gov/pubmed/36846022
http://dx.doi.org/10.3389/fimmu.2022.1073802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9947773/
https://www.ncbi.nlm.nih.gov/pubmed/36846022
http://dx.doi.org/10.3389/fimmu.2022.1073802

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