Cargando…

Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s Disease

[Image: see text] Herein, we rationally designed and developed two novel glitazones (G1 and G2) to target peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1α) signaling through peroxisome proliferator-activated receptors (PPAR)-γ agonism as a therapeutic for Parkinson’s dise...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prabhakaran, Prabitha, Nadig, Abhishek, M, Sahyadri, Tuladhar, Sunanda, Raju, Ruby Mariam, Chidambaram, Saravana Babu, Kempaiah, Bettadaiah Bheemanakere, Raghavendra, Nulgumnalli Manjunathaiah, Kumar BR, Prashantha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948211/ https://www.ncbi.nlm.nih.gov/pubmed/36844520 http://dx.doi.org/10.1021/acsomega.2c07521

Ejemplares similares

Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing Therapeutic Strategy through Mitochondrial Redox Dynamics against Neurodegeneration
por: Durai, Priya, et al.
Publicado: (2022)

Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies
por: Mandal, Subhankar P., et al.
Publicado: (2018)

Optimization of ultrasonic-assisted extraction of flavor compounds from shrimp by-products and characterization of flavor profile of the extract
por: Duppeti, Haritha, et al.
Publicado: (2023)

Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model
por: Justin, Antony, et al.
Publicado: (2020)

PPARδ Agonism Activates Fatty Acid Oxidation via PGC-1α but Does Not Increase Mitochondrial Gene Expression and Function
por: Kleiner, Sandra, et al.
Publicado: (2009)

Are the adverse effects of glitazones linked to induced testosterone deficiency?
por: Carruthers, M, et al.
Publicado: (2008)

Pleiotropic Effects of Glitazones: A Double Edge Sword?
por: Salomone, Salvatore
Publicado: (2011)

Glitazone use associated with reduced risk of Parkinson's disease
por: Brakedal, Brage, et al.
Publicado: (2017)

Atractylodin Ameliorates Colitis via PPARα Agonism
por: Heo, Gwangbeom, et al.
Publicado: (2023)

Novel derivatives of eugenol as potent anti-inflammatory agents via PPARγ agonism: rational design, synthesis, analysis, PPARγ protein binding assay and computational studies
por: Anjum, Noor Fathima, et al.
Publicado: (2022)

Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism
por: Kroker, Alice J., et al.
Publicado: (2015)

PPARδ Agonism for the Treatment of Obesity and Associated Disorders: Challenges and Opportunities
por: Perreault, Mylène, et al.
Publicado: (2008)

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
por: Boeckmans, Joost, et al.
Publicado: (2019)

Assessing the antimicrobial activities of Ocins
por: Choyam, Shilja, et al.
Publicado: (2015)

PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression
por: Rivera, Caroline N., et al.
Publicado: (2023)

Effect of glitazones on the progression of coronary artery disease in type 2 diabetes patients
por: Wyatt, Jamison, et al.
Publicado: (2010)

Changes in Glitazone Use Among Office-Based Physicians in the U.S., 2003–2009
por: Cohen, Andrew, et al.
Publicado: (2010)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
por: Lizcano, Fernando, et al.
Publicado: (2013)

Dual PPAR α/γ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia
por: Samuelsson, O., et al.
Publicado: (2013)

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
por: Brust, Richard, et al.
Publicado: (2018)

Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors
por: Bayindir‐Buchhalter, Irem, et al.
Publicado: (2018)

Glitazone Treatment Rescues Phenotypic Deficits in a Fly Model of Gaucher/Parkinson’s Disease
por: Shola-Dare, Oluwanifemi, et al.
Publicado: (2021)

Type 2 diabetes drug glitazone may help lowering risk of dementia by 22%
por: Fareed, Areeba, et al.
Publicado: (2023)

Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
por: Tenenbaum, Alexander, et al.
Publicado: (2005)

Oxaliplatin Neurotoxicity Involves Peroxisome Alterations. PPARγ Agonism as Preventive Pharmacological Approach
por: Zanardelli, Matteo, et al.
Publicado: (2014)

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
por: Corona, Juan Carlos, et al.
Publicado: (2014)

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis
por: Crossland, Hannah, et al.
Publicado: (2021)

Glitazone Treatment and Incidence of Parkinson’s Disease among People with Diabetes: A Retrospective Cohort Study
por: Brauer, Ruth, et al.
Publicado: (2015)

Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies
por: Pladevall, Manel, et al.
Publicado: (2016)

Molecular mechanism of agonism and inverse agonism in ghrelin receptor
por: Qin, Jiao, et al.
Publicado: (2022)

Comparative analysis of therapeutic efficiency and costs (experience in Bulgaria) of oral antidiabetic therapies based on glitazones and gliptins
por: Filipova, Elena Pavlova, et al.
Publicado: (2015)

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening
por: Mueller, Sarah L., et al.
Publicado: (2021)

Biased agonism
por: Kenakin, Terry
Publicado: (2009)

Agonizing Hedgehog
por: Weitzman, Jonathan B
Publicado: (2002)

Agon : ballet for twelve dancers
por: Stravinsky, Igor, 1882-1971
Publicado: (1957)

Muscle-Specific PPAR [Formula: see text] Agonism May Provide Synergistic Benefits with Life Style Modifications
por: Erol, Adnan
Publicado: (2007)

Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism
por: Nenov, Miroslav N., et al.
Publicado: (2014)

Woman with agonal breathing
por: Hsu, Chien‐Te, et al.
Publicado: (2023)

Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits
por: Cortez, Ibdanelo, et al.
Publicado: (2019)

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
por: Shizu, Ryota, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c7laem1huhhm7mhtqdit352k3d