Power and sample sizes estimation in clinical trials with treatment switching in intention-to-treat analysis: a simulation study

BACKGROUND: Treatment switching, also called crossover, is common in clinical trials because of ethical concerns or other reasons. When it occurs and the primary objective is to identify treatment effects, the most widely used intention-to-treat analysis may lead to underpowered trials. Here, we pre...

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Detalles Bibliográficos
Autores principales: Deng, Lejun, Hsu, Chih-Yuan, Shyr, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948351/
https://www.ncbi.nlm.nih.gov/pubmed/36823545
http://dx.doi.org/10.1186/s12874-023-01864-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948351/
https://www.ncbi.nlm.nih.gov/pubmed/36823545
http://dx.doi.org/10.1186/s12874-023-01864-1

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