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Power and sample sizes estimation in clinical trials with treatment switching in intention-to-treat analysis: a simulation study
BACKGROUND: Treatment switching, also called crossover, is common in clinical trials because of ethical concerns or other reasons. When it occurs and the primary objective is to identify treatment effects, the most widely used intention-to-treat analysis may lead to underpowered trials. Here, we pre...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948351/ https://www.ncbi.nlm.nih.gov/pubmed/36823545 http://dx.doi.org/10.1186/s12874-023-01864-1 |