Pitfalls and opportunities for applying latent variables in single-cell eQTL analyses

Using latent variables in gene expression data can help correct unobserved confounders and increase statistical power for expression quantitative trait Loci (eQTL) detection. The probabilistic estimation of expression residuals (PEER) and principal component analysis (PCA) are widely used methods th...

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Detalles Bibliográficos
Autores principales: Xue, Angli, Yazar, Seyhan, Neavin, Drew, Powell, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948363/
https://www.ncbi.nlm.nih.gov/pubmed/36823676
http://dx.doi.org/10.1186/s13059-023-02873-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948363/
https://www.ncbi.nlm.nih.gov/pubmed/36823676
http://dx.doi.org/10.1186/s13059-023-02873-5

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