Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity

Amblyomin-X is a Kunitz-type FXa inhibitor identified through the transcriptome analysis of the salivary gland from Amblyomma sculptum tick. This protein consists of two domains of equivalent size, triggers apoptosis in different tumor cell lines, and promotes regression of tumor growth, and reducti...

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Detalles Bibliográficos
Autores principales: Morais, K. L. P., Ciccone, L., Stura, E., Alvarez-Flores, M. P., Mourier, G., Driessche, M. Vanden, Sciani, J. M., Iqbal, A., Kalil, S. P., Pereira, G. J., Marques-Porto, R., Cunegundes, P., Juliano, L., Servent, D., Chudzinski-Tavassi, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948614/
https://www.ncbi.nlm.nih.gov/pubmed/36845546
http://dx.doi.org/10.3389/fmolb.2023.1072751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948614/
https://www.ncbi.nlm.nih.gov/pubmed/36845546
http://dx.doi.org/10.3389/fmolb.2023.1072751

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