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Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function

A perennial problem encountered when using small molecules (drugs) to manipulate cell or protein function is to assess whether observed changes in function result from specific interactions with a desired target or from less specific off-target mechanisms. This is important in laboratory research as...

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Detalles Bibliográficos
Autores principales: Peyear, Thasin A., Andersen, Olaf S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948646/
https://www.ncbi.nlm.nih.gov/pubmed/36763053
http://dx.doi.org/10.1085/jgp.202213247