Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor

Changes in the copy number of large genomic regions, termed copy number variations or CNVs, are an important adaptive strategy for malaria parasites. Numerous CNVs across the Plasmodium falciparum genome contribute directly to drug resistance or impact fitness of this protozoan parasite. CNVs that e...

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Detalles Bibliográficos
Autores principales: Liu, Shiwei, Ebel, Emily R., Kim, Jane, Ene, Nnenna, Braukmann, Thomas Werner Anthony, Yeh, Ellen, Egan, Elizabeth S., Guler, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948948/
https://www.ncbi.nlm.nih.gov/pubmed/36824743
http://dx.doi.org/10.1101/2023.02.13.528367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948948/
https://www.ncbi.nlm.nih.gov/pubmed/36824743
http://dx.doi.org/10.1101/2023.02.13.528367

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