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Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation

Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing cell-type specific exosome reporter mice, our...

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Detalles Bibliográficos
Autores principales: Jin, Shijie, Chen, Xuan, Tian, Yang, Jarvis, Rachel, Promes, Vanessa, Yang, Yongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9948960/
https://www.ncbi.nlm.nih.gov/pubmed/36824898
http://dx.doi.org/10.1101/2023.02.14.528554