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The Energetics and Ion Coupling of Cholesterol Transport Through Patched1

Patched1 (PTCH1) is the principal tumour suppressor protein of the mammalian Hedgehog (HH) signalling pathway, implicated in embryogenesis and tissue homeostasis. PTCH1 inhibits the Class F G protein-coupled receptor Smoothened (SMO) via a debated mechanism involving modulating accessible cholestero...

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Detalles Bibliográficos
Autores principales: Ansell, T. Bertie, Corey, Robin A., Viti, Lucrezia Vittoria, Kinnebrew, Maia, Rohatgi, Rajat, Siebold, Christian, Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949057/
https://www.ncbi.nlm.nih.gov/pubmed/36824746
http://dx.doi.org/10.1101/2023.02.14.528445