The Energetics and Ion Coupling of Cholesterol Transport Through Patched1

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Patched1 (PTCH1) is the principal tumour suppressor protein of the mammalian Hedgehog (HH) signalling pathway, implicated in embryogenesis and tissue homeostasis. PTCH1 inhibits the Class F G protein-coupled receptor Smoothened (SMO) via a debated mechanism involving modulating accessible cholestero...

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Detalles Bibliográficos
Autores principales: Ansell, T. Bertie, Corey, Robin A., Viti, Lucrezia Vittoria, Kinnebrew, Maia, Rohatgi, Rajat, Siebold, Christian, Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949057/
https://www.ncbi.nlm.nih.gov/pubmed/36824746
http://dx.doi.org/10.1101/2023.02.14.528445

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