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The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
The mammalian innate immune system uses germline-encoded cytosolic pattern-recognition receptors (PRRs) to detect intracellular danger signals. At least six of these PRRs are known to form multiprotein complexes called inflammasomes which activate cysteine proteases known as caspases. Canonical infl...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949112/ https://www.ncbi.nlm.nih.gov/pubmed/36824844 http://dx.doi.org/10.1101/2023.02.16.528859 |