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Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors

Phosphorylation of tau at sites associated with Alzheimer's disease (AD) likely plays a role in the disease progression. Mitochondrial impairment, correlating with increased presence of phosphorylated tau, has been identified as a contributing factor to neurodegenerative processes in AD. Howeve...

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Detalles Bibliográficos
Autores principales: Isei, Michael O, Girardi, Peter A, Rodwell-Bullock, Joel, Nehrke, Keith, Johnson, Gail VW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949115/
https://www.ncbi.nlm.nih.gov/pubmed/36824940
http://dx.doi.org/10.1101/2023.02.19.529131