Cargando…
Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors
Phosphorylation of tau at sites associated with Alzheimer's disease (AD) likely plays a role in the disease progression. Mitochondrial impairment, correlating with increased presence of phosphorylated tau, has been identified as a contributing factor to neurodegenerative processes in AD. Howeve...
Autores principales: | Isei, Michael O, Girardi, Peter A, Rodwell-Bullock, Joel, Nehrke, Keith, Johnson, Gail VW |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949115/ https://www.ncbi.nlm.nih.gov/pubmed/36824940 http://dx.doi.org/10.1101/2023.02.19.529131 |
Ejemplares similares
-
A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer’s disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons
por: Guha, Sanjib, et al.
Publicado: (2020) -
Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer’s Disease
por: Carroll, Trae, et al.
Publicado: (2021) -
Tauopathy-associated tau modifications selectively impact neurodegeneration and mitophagy in a novel C. elegans single-copy transgenic model
por: Guha, Sanjib, et al.
Publicado: (2020) -
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52
por: Jo, Chulman, et al.
Publicado: (2014) -
Mitochondrial Fragmentation Leads to Intracellular Acidification in Caenorhabditis elegans and Mammalian Cells
por: Johnson, David, et al.
Publicado: (2010)