Remodeling of colon plasma cell repertoire within ulcerative colitis patients

Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is unknown. We performed single-cell V(D)J- and RNA-seq on sorte...

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Detalles Bibliográficos
Autores principales: Scheid, Johannes F., Eraslan, Basak, Hudak, Andrew, Brown, Eric M., Sergio, Dallis, Delorey, Toni M., Phillips, Devan, Lefkovith, Ariel, Jess, Alison T., Duck, Lennard W., Elson, Charles O., Vlamakis, Hera, Plichta, Damian R., Deguine, Jacques, Ananthakrishnan, Ashwin N., Graham, Daniel B., Regev, Aviv, Xavier, Ramnik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949229/
https://www.ncbi.nlm.nih.gov/pubmed/36752797
http://dx.doi.org/10.1084/jem.20220538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949229/
https://www.ncbi.nlm.nih.gov/pubmed/36752797
http://dx.doi.org/10.1084/jem.20220538

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