Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells

Butyrophilin (BTN)-3A and BTN2A1 molecules control TCR-mediated activation of human Vγ9Vδ2 T-cells triggered by phosphoantigens (PAg) from microbes and tumors, but the molecular rules governing antigen sensing are unknown. Here we establish three mechanistic principles of PAg-action. Firstly, in hum...

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Detalles Bibliográficos
Autores principales: Karunakaran, Mohindar Murugesh, Subramanian, Hariharan, Jin, Yiming, Mohammed, Fiyaz, Kimmel, Brigitte, Juraske, Claudia, Starick, Lisa, Nöhren, Anna, Länder, Nora, Willcox, Carrie R., Singh, Rohit, Schamel, Wolfgang W., Nikolaev, Viacheslav O., Kunzmann, Volker, Wiemer, Andrew J., Willcox, Benjamin E., Herrmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949253/
https://www.ncbi.nlm.nih.gov/pubmed/36824912
http://dx.doi.org/10.21203/rs.3.rs-2583246/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949253/
https://www.ncbi.nlm.nih.gov/pubmed/36824912
http://dx.doi.org/10.21203/rs.3.rs-2583246/v1

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