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Distinct biological activity of Lewy body α-Synuclein strain in mice

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show distinct b...

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Detalles Bibliográficos
Autores principales: Uemura, Norihito, Marotta, Nicholas, Ara, Jahan, Meymand, Emily, Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin, Trojanowski, John, Lee, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949267/
https://www.ncbi.nlm.nih.gov/pubmed/36824782
http://dx.doi.org/10.21203/rs.3.rs-2579805/v1