Cargando…

Distinct biological activity of Lewy body α-Synuclein strain in mice

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural and functional properties. We recently demonstrated that aggregates amplified from LB-αSyn (ampLB) show distinct b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uemura, Norihito, Marotta, Nicholas, Ara, Jahan, Meymand, Emily, Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin, Trojanowski, John, Lee, Virginia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949267/ https://www.ncbi.nlm.nih.gov/pubmed/36824782 http://dx.doi.org/10.21203/rs.3.rs-2579805/v1

Ejemplares similares

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice
por: Uemura, Norihito, et al.
Publicado: (2023)

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
por: Marotta, Nicholas P., et al.
Publicado: (2021)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

α-Synuclein modulates tau spreading in mouse brains
por: Bassil, Fares, et al.
Publicado: (2020)

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
por: Uemura, Norihito, et al.
Publicado: (2018)

Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
por: Uemura, Norihito, et al.
Publicado: (2019)

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
por: Luk, Kelvin C., et al.
Publicado: (2012)

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes
por: Volpicelli-Daley, Laura A., et al.
Publicado: (2014)

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
por: Suzuki, Genjiro, et al.
Publicado: (2020)

Structures of α-synuclein filaments from human brains with Lewy pathology
por: Yang, Yang, et al.
Publicado: (2022)

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy
por: Ayers, Jacob I., et al.
Publicado: (2022)

α-Synuclein Strains and Their Relevance to Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy Bodies
por: Graves, Noah J., et al.
Publicado: (2023)

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril
por: Kim, Changyoun, et al.
Publicado: (2016)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
por: Rey, Nolwen L., et al.
Publicado: (2017)

Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson’s disease
por: Matsui, Hideaki, et al.
Publicado: (2023)

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples
por: Puentes, Laura N., et al.
Publicado: (2021)

α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
por: Kasuga, Kensaku, et al.
Publicado: (2012)

α-Synuclein Strains Target Distinct Brain Regions and Cell Types
por: Lau, Angus, et al.
Publicado: (2019)

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
por: Osterberg, Valerie R., et al.
Publicado: (2015)

Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1
por: Miners, J Scott, et al.
Publicado: (2014)

α-Synuclein arginylation in the human brain
por: Zhao, Jun, et al.
Publicado: (2022)

Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)
por: Nakanishi, Etsuro, et al.
Publicado: (2021)

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein
por: Sekigawa, Akio, et al.
Publicado: (2012)

Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
por: Morris, Meaghan, et al.
Publicado: (2015)

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
por: van Steenoven, Inger, et al.
Publicado: (2018)

A toxic subset of soluble α-synuclein species in dementia with Lewy body
por: Castillo-Carranza, Diana L
Publicado: (2020)

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein
por: Leitão, André D. G., et al.
Publicado: (2021)

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
por: Simon, Christopher, et al.
Publicado: (2021)

Investigating key factors underlying neurodegeneration linked to alpha‐synuclein spread
por: Pang, Cindy C. C., et al.
Publicado: (2022)

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
por: Henderson, Michael X., et al.
Publicado: (2018)

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein
por: Uemura, Norihito, et al.
Publicado: (2015)

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease
por: Al-Hilaly, Youssra K., et al.
Publicado: (2016)

α‐synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease
por: Spencer, Brian, et al.
Publicado: (2016)

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
por: Ngolab, Jennifer, et al.
Publicado: (2017)

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
por: Iba, Michiyo, et al.
Publicado: (2020)

The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease
por: García‐Sanz, Patricia, et al.
Publicado: (2020)

Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
por: Miller, Rebecca L., et al.
Publicado: (2022)

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
por: Hoban, Deirdre B., et al.
Publicado: (2020)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_p7730q7mp513p8mehummhqk30a