The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination

BACKGROUND: The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of immune checkpoint inhibitors such as PD1/PD-L1 antibodies. METHODS: Mapping of the OPSCC HLA ligandome was performed by mass spectrometry (MS) b...

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Detalles Bibliográficos
Autores principales: Mühlenbruch, Lena, Abou-Kors, Tsima, Dubbelaar, Marissa L., Bichmann, Leon, Kohlbacher, Oliver, Bens, Martin, Thomas, Jaya, Ezić, Jasmin, Kraus, Johann M., Kestler, Hans A., von Witzleben, Adrian, Mytilineos, Joannis, Fürst, Daniel, Engelhardt, Daphne, Doescher, Johannes, Greve, Jens, Schuler, Patrick J., Theodoraki, Marie-Nicole, Brunner, Cornelia, Hoffmann, Thomas K., Rammensee, Hans-Georg, Walz, Juliane S., Laban, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949688/
https://www.ncbi.nlm.nih.gov/pubmed/36823366
http://dx.doi.org/10.1038/s41416-023-02197-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949688/
https://www.ncbi.nlm.nih.gov/pubmed/36823366
http://dx.doi.org/10.1038/s41416-023-02197-y

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