Cargando…

The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination

BACKGROUND: The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of immune checkpoint inhibitors such as PD1/PD-L1 antibodies. METHODS: Mapping of the OPSCC HLA ligandome was performed by mass spectrometry (MS) b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mühlenbruch, Lena, Abou-Kors, Tsima, Dubbelaar, Marissa L., Bichmann, Leon, Kohlbacher, Oliver, Bens, Martin, Thomas, Jaya, Ezić, Jasmin, Kraus, Johann M., Kestler, Hans A., von Witzleben, Adrian, Mytilineos, Joannis, Fürst, Daniel, Engelhardt, Daphne, Doescher, Johannes, Greve, Jens, Schuler, Patrick J., Theodoraki, Marie-Nicole, Brunner, Cornelia, Hoffmann, Thomas K., Rammensee, Hans-Georg, Walz, Juliane S., Laban, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949688/ https://www.ncbi.nlm.nih.gov/pubmed/36823366 http://dx.doi.org/10.1038/s41416-023-02197-y

Ejemplares similares

Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma
por: Mytilineos, Daphne, et al.
Publicado: (2020)

HLA ligandome tumor antigen discovery for personalized vaccine approach
por: Rammensee, Hans-Georg, et al.
Publicado: (2013)

HLA ligandomics identifies histone deacetylase 1 as target for ovarian cancer immunotherapy
por: Peper, Janet Kerstin, et al.
Publicado: (2015)

Comparison of plasma- and saliva-derived exosomal miRNA profiles reveals diagnostic potential in head and neck cancer
por: Hofmann, Linda, et al.
Publicado: (2022)

Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
por: Reustle, Anna, et al.
Publicado: (2020)

BTK Isoforms p80 and p65 Are Expressed in Head and Neck Squamous Cell Carcinoma (HNSCC) and Involved in Tumor Progression
por: Betzler, Annika C., et al.
Publicado: (2023)

Demographics and access to head and neck cancer care in rural areas compared to urban areas in Germany
por: Vahl, Julius M., et al.
Publicado: (2023)

Targeting the MHC Ligandome by Use of TCR-Like Antibodies
por: Høydahl, Lene Støkken, et al.
Publicado: (2019)

Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome*
por: Mylonas, Roman, et al.
Publicado: (2018)

T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation
por: Betzler, Annika C., et al.
Publicado: (2022)

Pitfalls in HLA Ligandomics—How to Catch a Li(e)gand
por: Fritsche, Jens, et al.
Publicado: (2021)

Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions
por: von Witzleben, Adrian, et al.
Publicado: (2022)

Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics
por: Wacker, Marcel, et al.
Publicado: (2023)

Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
por: Huber, Lisa T., et al.
Publicado: (2023)

‘Hotspots’ of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization
por: Müller, Markus, et al.
Publicado: (2017)

Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma
por: Jeske, S. S., et al.
Publicado: (2020)

Characterization and Differentiation of the Tumor Microenvironment (TME) of Orthotopic and Subcutaneously Grown Head and Neck Squamous Cell Carcinoma (HNSCC) in Immunocompetent Mice
por: Brand, Matthias, et al.
Publicado: (2020)

Cargo and Functional Profile of Saliva-Derived Exosomes Reveal Biomarkers Specific for Head and Neck Cancer
por: Hofmann, Linda, et al.
Publicado: (2022)

Common and well‐documented HLA alleles of German stem cell donors by haplotype frequency estimation
por: Eberhard, Hans‐Peter, et al.
Publicado: (2018)

Increasing Mean Age of Head and Neck Cancer Patients at a German Tertiary Referral Center
por: Vahl, Julius M., et al.
Publicado: (2021)

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome
por: Demmers, Laura C., et al.
Publicado: (2019)

NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors
por: Chitadze, Guranda, et al.
Publicado: (2015)

Human leukocyte antigen-E mismatch is associated with better hematopoietic stem cell transplantation outcome in acute leukemia patients
por: Tsamadou, Chrysanthi, et al.
Publicado: (2017)

Changes in Gene Expression Patterns in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Under Chemoradiotherapy Depend on Response
por: Doescher, Johannes, et al.
Publicado: (2022)

Sampling From the Proteome to the Human Leukocyte Antigen-DR (HLA-DR) Ligandome Proceeds Via High Specificity
por: Mommen, Geert P. M., et al.
Publicado: (2016)

What Is the Role of HLA-I on Cancer Derived Extracellular Vesicles? Defining the Challenges in Characterisation and Potential Uses of This Ligandome
por: Boyne, Caitlin, et al.
Publicado: (2021)

The Impact of Biomaterial Cell Contact on the Immunopeptidome
por: Ghosh, Michael, et al.
Publicado: (2020)

Eculizumab in chemotherapy-induced thrombotic microangiopathy
por: Schulte-Kemna, Lena, et al.
Publicado: (2020)

Tumour‐associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles
por: Kumar, Pankaj, et al.
Publicado: (2022)

Identification of HCMV-derived T cell epitopes in seropositive individuals through viral deletion models
por: Lübke, Maren, et al.
Publicado: (2019)

High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome
por: Chong, Chloe, et al.
Publicado: (2018)

The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02
por: Mukherjee, Soumya, et al.
Publicado: (2021)

Ligandomes obtained from different HLA-class II-molecules are homologous for N- and C-terminal residues outside the peptide-binding cleft
por: Kampstra, Arieke S.B., et al.
Publicado: (2019)

Impact of Donor Activating KIR Genes on HSCT Outcome in C1-Ligand Negative Myeloid Disease Patients Transplanted with Unrelated Donors—A Retrospective Study
por: Neuchel, Christine, et al.
Publicado: (2017)

Increased age-associated mortality risk in HLA-mismatched hematopoietic stem cell transplantation
por: Fürst, Daniel, et al.
Publicado: (2017)

HLA Ligand Atlas: a benign reference of HLA-presented peptides to improve T-cell-based cancer immunotherapy
por: Marcu, Ana, et al.
Publicado: (2021)

Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy
por: Puntigam, Lisa K., et al.
Publicado: (2020)

Circulating Exosomes Inhibit B Cell Proliferation and Activity
por: Schroeder, Jan C., et al.
Publicado: (2020)

Understanding the constitutive presentation of MHC class I immunopeptidomes in primary tissues
por: Kubiniok, Peter, et al.
Publicado: (2022)

The Peptide Vaccine of the Future
por: Nelde, Annika, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lgoj4int9154utjgttuiso7rod