Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T-cell Function With Implications for Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a common and incurable B-cell malignancy. Recent therapeutic approaches that target the B-cell receptor signaling pathway include inhibition of phosphatidylinositol-3-kinase (PI3K). The PI3K isoform delta is constitutively active in CLL, making it an attractive...

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Detalles Bibliográficos
Autores principales: Faehling, Sebastian, Coelho, Mariana, Floerchinger, Alessia, Schneider, Christof, Stilgenbauer, Stephan, Lichter, Peter, Seiffert, Martina, Roessner, Philipp M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949793/
https://www.ncbi.nlm.nih.gov/pubmed/36844182
http://dx.doi.org/10.1097/HS9.0000000000000840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949793/
https://www.ncbi.nlm.nih.gov/pubmed/36844182
http://dx.doi.org/10.1097/HS9.0000000000000840

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