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Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T-cell Function With Implications for Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a common and incurable B-cell malignancy. Recent therapeutic approaches that target the B-cell receptor signaling pathway include inhibition of phosphatidylinositol-3-kinase (PI3K). The PI3K isoform delta is constitutively active in CLL, making it an attractive...

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Detalles Bibliográficos
Autores principales:	Faehling, Sebastian, Coelho, Mariana, Floerchinger, Alessia, Schneider, Christof, Stilgenbauer, Stephan, Lichter, Peter, Seiffert, Martina, Roessner, Philipp M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949793/ https://www.ncbi.nlm.nih.gov/pubmed/36844182 http://dx.doi.org/10.1097/HS9.0000000000000840

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