RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

CD47 is a macrophage-specific immune checkpoint protein acting by inhibiting phagocytosis. However, the underlying mechanism maintaining CD47 protein stability in cancer is not clear. Here we show that CD47 undergoes degradation via endocytosis/lysosome pathway. The lysosome protein RAGA interacts w...

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Detalles Bibliográficos
Autores principales: Zhang, Lian, Yu, Jing, Zheng, Mingyue, Zhen, Hui, Xie, Qingqiang, Zhang, Chundong, Zhou, Zhongjun, Jin, Guoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950044/
https://www.ncbi.nlm.nih.gov/pubmed/36823443
http://dx.doi.org/10.1038/s42003-023-04581-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950044/
https://www.ncbi.nlm.nih.gov/pubmed/36823443
http://dx.doi.org/10.1038/s42003-023-04581-z

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