Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

Lysophosphatidylserine (LysoPS) is a lipid mediator that induces multiple cellular responses through binding to GPR174. Here, we present the cryo-electron microscopy (cryo-EM) structure of LysoPS-bound human GPR174 in complex with G(s) protein. The structure reveals a ligand recognition mode, includ...

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Detalles Bibliográficos
Autores principales: Liang, Jiale, Inoue, Asuka, Ikuta, Tatsuya, Xia, Ruixue, Wang, Na, Kawakami, Kouki, Xu, Zhenmei, Qian, Yu, Zhu, Xinyan, Zhang, Anqi, Guo, Changyou, Huang, Zhiwei, He, Yuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950150/
https://www.ncbi.nlm.nih.gov/pubmed/36823105
http://dx.doi.org/10.1038/s41467-023-36575-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950150/
https://www.ncbi.nlm.nih.gov/pubmed/36823105
http://dx.doi.org/10.1038/s41467-023-36575-0

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