DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis

The acidic, hypoxic and nutrient-deprived tumor microenvironment may induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may exert an important cytoprotective role by promoting folding of newly synthesized proteins and cancer cell survival. The lack of DNMT2/TRDMT1 methy...

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Detalles Bibliográficos
Autores principales: Adamczyk-Grochala, Jagoda, Bloniarz, Dominika, Zielinska, Klaudia, Lewinska, Anna, Wnuk, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950192/
https://www.ncbi.nlm.nih.gov/pubmed/36273376
http://dx.doi.org/10.1007/s10495-022-01779-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950192/
https://www.ncbi.nlm.nih.gov/pubmed/36273376
http://dx.doi.org/10.1007/s10495-022-01779-0

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