White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

We postulate that myelin injury contributes to cholesterol release from myelin and cholesterol dysmetabolism which contributes to Abeta dysmetabolism, and combined with genetic and AD risk factors, leads to increased Abeta and amyloid plaques. Increased Abeta damages myelin to form a vicious injury...

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Detalles Bibliográficos
Autores principales: Sharp, Frank R., DeCarli, Charles S., Jin, Lee-Way, Zhan, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950279/
https://www.ncbi.nlm.nih.gov/pubmed/36845656
http://dx.doi.org/10.3389/fnagi.2023.1096206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950279/
https://www.ncbi.nlm.nih.gov/pubmed/36845656
http://dx.doi.org/10.3389/fnagi.2023.1096206

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