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Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan

Our previous work identified one region upstream human UGT2B4 (UDP glucuronosyltransferase family 2 member B4) which is associated with breast cancer and under balancing selection. However, the distribution, functional variation and molecular mechanism underlying breast cancer and balancing selectio...

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Detalles Bibliográficos
Autores principales: Wang, Pin-Yi, Yang, Yuan, Shi, Xiao-Qian, Chen, Ying, Liu, Shao-Dong, Wang, Hong-Yan, Peng, Tao, Shi, Qiang, Zhang, Wei, Sun, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950360/
https://www.ncbi.nlm.nih.gov/pubmed/36823244
http://dx.doi.org/10.1038/s41598-023-29682-x