Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway

The role of autophagy in cancer is context-dependent. In the present study, we aimed to investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin (SIRT) family member, SIRT4, was significantly associated autophagy pathway in pancreatic ductal adenocarcinoma (PDAC). Spe...

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Detalles Bibliográficos
Autores principales: Li, Juan, Zhan, Hanxiang, Ren, Yidan, Feng, Maoxiao, Wang, Qin, Jiao, Qinlian, Wang, Yuli, Liu, Xiaoyan, Zhang, Shujun, Du, Lutao, Wang, Yunshan, Wang, Chuanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950374/
https://www.ncbi.nlm.nih.gov/pubmed/36209169
http://dx.doi.org/10.1038/s41418-022-01063-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950374/
https://www.ncbi.nlm.nih.gov/pubmed/36209169
http://dx.doi.org/10.1038/s41418-022-01063-3

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