PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses, we show a heterogeneity between metabolite and transcript profiles. Specifically, the level of serine in hepatocellula...

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Detalles Bibliográficos
Autores principales: Wang, Kui, Luo, Li, Fu, Shuyue, Wang, Mao, Wang, Zihao, Dong, Lixia, Wu, Xingyun, Dai, Lunzhi, Peng, Yong, Shen, Guobo, Chen, Hai-Ning, Nice, Edouard Collins, Wei, Xiawei, Huang, Canhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950448/
https://www.ncbi.nlm.nih.gov/pubmed/36823188
http://dx.doi.org/10.1038/s41467-023-36708-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950448/
https://www.ncbi.nlm.nih.gov/pubmed/36823188
http://dx.doi.org/10.1038/s41467-023-36708-5

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