Structure of human Na(V)1.6 channel reveals Na(+) selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

The sodium channel Na(V)1.6 is widely expressed in neurons of the central and peripheral nervous systems, which plays a critical role in regulating neuronal excitability. Dysfunction of Na(V)1.6 has been linked to epileptic encephalopathy, intellectual disability and movement disorders. Here we pres...

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Detalles Bibliográficos
Autores principales: Li, Yue, Yuan, Tian, Huang, Bo, Zhou, Feng, Peng, Chao, Li, Xiaojing, Qiu, Yunlong, Yang, Bei, Zhao, Yan, Huang, Zhuo, Jiang, Daohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950489/
https://www.ncbi.nlm.nih.gov/pubmed/36823201
http://dx.doi.org/10.1038/s41467-023-36766-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950489/
https://www.ncbi.nlm.nih.gov/pubmed/36823201
http://dx.doi.org/10.1038/s41467-023-36766-9

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