THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass

Impaired insulin secretion is a hallmark in type 2 diabetes mellitus (T2DM). THADA has been identified as a candidate gene for T2DM, but its role in glucose homeostasis remains elusive. Here we report that THADA is strongly activated in human and mouse islets of T2DM. Both global and β-cell-specific...

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Detalles Bibliográficos
Autores principales: Zhang, Yuqing, Han, Shan, Liu, Congcong, Zheng, Yuanwen, Li, Hao, Gao, Fei, Bian, Yuehong, Liu, Xin, Liu, Hongbin, Hu, Shourui, Li, Yuxuan, Chen, Zi-Jiang, Zhao, Shigang, Zhao, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950491/
https://www.ncbi.nlm.nih.gov/pubmed/36823211
http://dx.doi.org/10.1038/s41467-023-36680-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950491/
https://www.ncbi.nlm.nih.gov/pubmed/36823211
http://dx.doi.org/10.1038/s41467-023-36680-0

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