Novel genetically engineered H3.3G34R model reveals cooperation with ATRX loss in upregulation of Hoxa cluster genes and promotion of neuronal lineage

BACKGROUND: Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently de...

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Detalles Bibliográficos
Autores principales: Abdallah, Aalaa S, Cardona, Herminio J, Gadd, Samantha L, Brat, Daniel J, Powla, Plamena P, Alruwalli, Waleed S, Shen, Chen, Picketts, David J, Li, Xiao-Nan, Becher, Oren J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950856/
https://www.ncbi.nlm.nih.gov/pubmed/36845293
http://dx.doi.org/10.1093/noajnl/vdad003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950856/
https://www.ncbi.nlm.nih.gov/pubmed/36845293
http://dx.doi.org/10.1093/noajnl/vdad003

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