Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice

OBJECTIVE: The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse. METHODS: ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet containing pacritinib. Body weight was mon...

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Detalles Bibliográficos
Autores principales: Petrova, Tsvetana, Figueras-Vadillo, Clara, Nanda, Sambit K, Scudamore, Cheryl, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950973/
https://www.ncbi.nlm.nih.gov/pubmed/36822800
http://dx.doi.org/10.1136/lupus-2022-000822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950973/
https://www.ncbi.nlm.nih.gov/pubmed/36822800
http://dx.doi.org/10.1136/lupus-2022-000822

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