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Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
OBJECTIVE: The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse. METHODS: ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet containing pacritinib. Body weight was mon...
Autores principales: | Petrova, Tsvetana, Figueras-Vadillo, Clara, Nanda, Sambit K, Scudamore, Cheryl, Cohen, Philip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950973/ https://www.ncbi.nlm.nih.gov/pubmed/36822800 http://dx.doi.org/10.1136/lupus-2022-000822 |
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