Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models

BACKGROUND: Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of ‘effector’ Tregs in particular is associated with an inferior prognosis in patients on standard rituximab plus cyclophosphamide, doxorubici...

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Detalles Bibliográficos
Autores principales: Stirm, Kristin, Leary, Peter, Wüst, Daria, Stark, Dominique, Joller, Nicole, Karakus, Ufuk, Boyman, Onur, Tzankov, Alexandar, Müller, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950978/
https://www.ncbi.nlm.nih.gov/pubmed/36822670
http://dx.doi.org/10.1136/jitc-2022-006263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950978/
https://www.ncbi.nlm.nih.gov/pubmed/36822670
http://dx.doi.org/10.1136/jitc-2022-006263

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