T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma

BACKGROUND: Immune checkpoint blockade (ICB) monotherapy provides poor survival benefit in hepatocellular carcinoma (HCC) due to ICB resistance caused by immunosuppressive tumor microenvironment (TME) and drug discontinuation resulting from immune-related side effects. Thus, novel strategies that ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaobin, Zhang, Qiaoyun, Zhou, Jingwen, Xiao, Zecong, Liu, Jianxin, Deng, Shaohui, Hong, Xiaoyang, Huang, Wensou, Cai, Mingyue, Guo, Yongjian, Huang, Jingjun, Wang, Yong, Lin, Liteng, Zhu, Kangshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950981/
https://www.ncbi.nlm.nih.gov/pubmed/36813307
http://dx.doi.org/10.1136/jitc-2022-006493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950981/
https://www.ncbi.nlm.nih.gov/pubmed/36813307
http://dx.doi.org/10.1136/jitc-2022-006493

Ejemplares similares