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T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma

BACKGROUND: Immune checkpoint blockade (ICB) monotherapy provides poor survival benefit in hepatocellular carcinoma (HCC) due to ICB resistance caused by immunosuppressive tumor microenvironment (TME) and drug discontinuation resulting from immune-related side effects. Thus, novel strategies that ca...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaobin, Zhang, Qiaoyun, Zhou, Jingwen, Xiao, Zecong, Liu, Jianxin, Deng, Shaohui, Hong, Xiaoyang, Huang, Wensou, Cai, Mingyue, Guo, Yongjian, Huang, Jingjun, Wang, Yong, Lin, Liteng, Zhu, Kangshun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950981/ https://www.ncbi.nlm.nih.gov/pubmed/36813307 http://dx.doi.org/10.1136/jitc-2022-006493

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