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The bidirectional interaction of COVID-19 infections and lipoproteins
COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I, A-II, and B levels while triglyceride levels may be increased or inappropriately normal for the poor nutritional status. The degree of reduction in total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I are predic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Author(s). Published by Elsevier Ltd.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951034/ https://www.ncbi.nlm.nih.gov/pubmed/36894344 http://dx.doi.org/10.1016/j.beem.2023.101751 |
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author | Feingold, Kenneth R. |
author_facet | Feingold, Kenneth R. |
author_sort | Feingold, Kenneth R. |
collection | PubMed |
description | COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I, A-II, and B levels while triglyceride levels may be increased or inappropriately normal for the poor nutritional status. The degree of reduction in total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I are predictive of mortality. With recovery lipid/lipoprotein levels return towards pre-infection levels and studies have even suggested an increased risk of dyslipidemia post-COVID-19 infection. The potential mechanisms for these changes in lipid and lipoprotein levels are discussed. Decreased HDL-C and apolipoprotein A-I levels measured many years prior to COVID-19 infections are associated with an increased risk of severe COVID-19 infections while LDL-C, apolipoprotein B, Lp (a), and triglyceride levels were not consistently associated with an increased risk. Finally, data suggest that omega-3-fatty acids and PCSK9 inhibitors may reduce the severity of COVID-19 infections. Thus, COVID-19 infections alter lipid/lipoprotein levels and HDL-C levels may affect the risk of developing COVID-19 infections. |
format | Online Article Text |
id | pubmed-9951034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author(s). Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99510342023-02-24 The bidirectional interaction of COVID-19 infections and lipoproteins Feingold, Kenneth R. Best Pract Res Clin Endocrinol Metab Article COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I, A-II, and B levels while triglyceride levels may be increased or inappropriately normal for the poor nutritional status. The degree of reduction in total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I are predictive of mortality. With recovery lipid/lipoprotein levels return towards pre-infection levels and studies have even suggested an increased risk of dyslipidemia post-COVID-19 infection. The potential mechanisms for these changes in lipid and lipoprotein levels are discussed. Decreased HDL-C and apolipoprotein A-I levels measured many years prior to COVID-19 infections are associated with an increased risk of severe COVID-19 infections while LDL-C, apolipoprotein B, Lp (a), and triglyceride levels were not consistently associated with an increased risk. Finally, data suggest that omega-3-fatty acids and PCSK9 inhibitors may reduce the severity of COVID-19 infections. Thus, COVID-19 infections alter lipid/lipoprotein levels and HDL-C levels may affect the risk of developing COVID-19 infections. The Author(s). Published by Elsevier Ltd. 2023-02-24 /pmc/articles/PMC9951034/ /pubmed/36894344 http://dx.doi.org/10.1016/j.beem.2023.101751 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Feingold, Kenneth R. The bidirectional interaction of COVID-19 infections and lipoproteins |
title | The bidirectional interaction of COVID-19 infections and lipoproteins |
title_full | The bidirectional interaction of COVID-19 infections and lipoproteins |
title_fullStr | The bidirectional interaction of COVID-19 infections and lipoproteins |
title_full_unstemmed | The bidirectional interaction of COVID-19 infections and lipoproteins |
title_short | The bidirectional interaction of COVID-19 infections and lipoproteins |
title_sort | bidirectional interaction of covid-19 infections and lipoproteins |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951034/ https://www.ncbi.nlm.nih.gov/pubmed/36894344 http://dx.doi.org/10.1016/j.beem.2023.101751 |
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