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Constant domain polymorphisms influence monoclonal antibody stability and dynamics

The constant regions of clinical monoclonal antibodies are derived from a select number of allotypes found in IgG subclasses. Despite a long‐term acknowledgment that this diversity may impact both antibody function and developability, there is a lack of data on the stability of variants carrying the...

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Detalles Bibliográficos
Autores principales: Warrender, Annmaree K., Pan, Jolyn, Pudney, Chris R., Arcus, Vickery L., Kelton, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951194/
https://www.ncbi.nlm.nih.gov/pubmed/36759959
http://dx.doi.org/10.1002/pro.4589