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Constant domain polymorphisms influence monoclonal antibody stability and dynamics

The constant regions of clinical monoclonal antibodies are derived from a select number of allotypes found in IgG subclasses. Despite a long‐term acknowledgment that this diversity may impact both antibody function and developability, there is a lack of data on the stability of variants carrying the...

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Detalles Bibliográficos
Autores principales:	Warrender, Annmaree K., Pan, Jolyn, Pudney, Chris R., Arcus, Vickery L., Kelton, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Full‐length Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951194/ https://www.ncbi.nlm.nih.gov/pubmed/36759959 http://dx.doi.org/10.1002/pro.4589

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