NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats

Herein, we describe the generation of potent NK cell engagers (NKCEs) based on single domain antibodies (sdAbs) specific for NKp46 harboring the humanized Fab version of Cetuximab for tumor targeting. After immunization of camelids, a plethora of different VHH domains were retrieved by yeast surface...

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Detalles Bibliográficos
Autores principales: Lipinski, Britta, Arras, Paul, Pekar, Lukas, Klewinghaus, Daniel, Boje, Ammelie Svea, Krah, Simon, Zimmermann, Jasmin, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951198/
https://www.ncbi.nlm.nih.gov/pubmed/36775946
http://dx.doi.org/10.1002/pro.4593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951198/
https://www.ncbi.nlm.nih.gov/pubmed/36775946
http://dx.doi.org/10.1002/pro.4593

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